In 1444 the King of Hungary, Ladislas Posthumous, broke the peace and launched the Varna campaign under the command of John Hunyadi in an effort to drive the Turks out of Europe. Hunyadi demanded that Vlad II fulfill his oath as a member of the Order of the Dragon and a vassal of Hungary and join the crusade against the Turk. Rather than join the Christian forces himself he sent his oldest son, Mircea. Perhaps he hoped the sultan would spare his younger sons if he himself did not join the crusade.

The results of the Varna Crusade are well known. The Christian army was utterly destroyed in the Battle of Varna. John Hunyadi managed to escape the battle under conditions that add little glory to the White Knight's reputation. Many, apparently including Mircea and his father, blamed Hunyadi for the debacle. From this moment forth John Hunyadi was bitterly hostile toward Vlad Dracul and his eldest son. In 1447 Vlad Dracul was assassinated along with his son Mircea. Mircea was apparently buried alive by the boyars and merchants of Tirgoviste. Hunyadi placed his own candidate, Vladislav II, a member of the Danesti clan, on the throne of Wallachia.

On receiving the news of Vlad Dracul's death the Turks released Dracula and supported him as their own candidate for the Wallachian throne. In 1448 Dracula managed to briefly seize the Wallachian throne with Turkish support. Within two months Hunyadi forced Dracula to surrender the throne and flee to his cousin, the Prince of Moldavia, while Hunyadi once again placed Vladislav II on the Wallachian throne.

Dracula remained in exile in Moldavia for three years, until Prince Bogdan of Moldavia was assassinated in 1451. The resulting turmoil in Moldavia forced Dracula to flee to Transylvania and seek the protection of his family enemy, Hunyadi. The timing was propitious; Hunaydi's puppet on the Wallachian throne, Vladislav II, had instituted a pro-Turkish policy and Hunyadi needed a more reliable man in Wallachia. Consequently, Hunyadi accepted the allegiance of his old enemy's son and put him forward as the Hungarian candidate for the throne of Wallachia. Dracula became Hunyadi's vassal and received his father's old Transylvanian duchies of Faragas and Almas.

Dracula remained in Transylvania, under Hunyadi's protection, until 1456 waiting for an opportunity to retake Wallachia from his rival.

In 1453 the Christian world was shocked by the final fall of Constantinople to the Ottomans. The East Roman Empire which had existed since the time of Constantine the Great and which for a thousand years had shielded the rest of Christendom from Islam was no more. Hunyadi immediately began planning another campaign against the Turks.

In 1456 Hunyadi invaded Turkish Serbia while Dracula simultaneously invaded Wallachia. In the Battle of Belgrade Hunyadi was killed and his army defeated. Meanwhile, Dracula succeeded in killing Vladislav II and taking the Wallachian throne but Hunaydi's defeat made his long term tenure questionable. For a time at least, Dracula was forced to attempt to placate the Turks while he solidified his own position.